Project overview
This randomized controlled trial assessed the long-term efficacy of Platelet-Rich Plasma (PRP) therapy in managing chronic knee joint pain. A total of 1,000 patients aged 40–80 with osteoarthritis were enrolled and randomized into PRP and placebo (saline) groups. Treatments were administered at baseline, one, and two months, with follow-up extending to five years. PRP-treated patients demonstrated significant and sustained improvements in pain and function, as measured by VAS and WOMAC scores, compared to placebo. Although minor adverse effects such as injection site pain and swelling were more common in the PRP group, they were manageable and transient. This large-scale study affirms PRP’s long-term benefits and supports its incorporation into clinical protocols for non-surgical knee pain management. PRP therapy emerges as a safe, effective, and durable option that can enhance joint function and quality of life in patients with degenerative knee conditions.
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