Project overview
This prospective study evaluated 39 patients with intracranial space-occupying lesions (ICSOL) using MRI and Magnetic Resonance Spectroscopy (MRS) at a tertiary care center to enhance diagnostic accuracy. While MRI provided anatomical localization, MRS delivered metabolic profiles that helped differentiate between neoplastic and infectious lesions. Among 30 patients with valid spectroscopic data, gliomas were most common (56%), followed by metastases and infections. High-grade gliomas displayed elevated choline-to-creatine (Cho/Cr) and choline-to-N-acetyl aspartate (Cho/NAA) ratios with lactate–lipid peaks, while meningiomas featured alanine peaks, and abscesses showed amino-acid signals. Combined MRI+MRS yielded a diagnostic accuracy of 83.3%, outperforming MRI alone (71%). MRS helped delineate tumor grades, distinguish infections from necrotic tumors, and informed biopsy planning. Although nine patients could not undergo MRS due to technical limitations
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