Project overview
This one-year, hospital-based comparative study investigated the effectiveness of intra-articular autologous platelet-rich plasma (PRP) versus corticosteroid (CS) injections in managing knee osteoarthritis (OA). Fifty patients with mild to moderate OA were evenly divided into two treatment groups and monitored using validated pain and function measures (VAS, WOMAC, KOOS) at 0, 3, and 6 months. The demographic distribution (age, sex, KL grade, and knee side) showed no significant association with the type of treatment administered, ensuring unbiased allocation. Results revealed that corticosteroids offered quicker symptom relief at the 3-month follow-up but waned significantly by 6 months, as indicated by rising VAS scores. In contrast, PRP showed a slower onset of action but demonstrated more sustained pain relief and functional improvement, especially evident at 6 months, with statistically significant changes in KOOS scores and trends favoring PRP in WOMAC.
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