Project overview
This cross-sectional study conducted in North India evaluated 96 clinically diagnosed cases of puerperal sepsis, investigating microbial causes and antibiotic resistance using both traditional microbiology and MALDI-TOF MS. The majority of infections were caused by gram-negative organisms, notably Escherichia coli (43.5%) and Klebsiella pneumoniae (29%). MALDI-TOF MS improved the specificity of pathogen identification, especially for less common bacteria. High rates of antibiotic resistance were noted, including resistance to penicillins, cephalosporins, and carbapenems, with MRSA also identified among gram-positive isolates. Significant risk factors included anemia (OR = 6.02), prolonged labor, prelabor rupture of membranes (PROM), and multiple vaginal examinations. The study underscores the urgent need for rapid pathogen detection, targeted antibiotic therapy, improved antenatal care, and stringent infection control to mitigate maternal morbidity.
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