Project overview
This prospective observational study evaluated the prognostic role of NT-proBNP levels in 100 patients under 60 years of age diagnosed with Acute Coronary Syndromes (ACS), including STEMI, NSTEMI, and unstable angina. NT-proBNP, a biomarker reflecting myocardial wall stress, was measured within 2–24 hours of symptom onset and stratified into three groups: <100 pg/mL, 100–500 pg/mL, and >500 pg/mL. Clinical outcomes over six months—such as recurrent chest pain, dyspnea, palpitations, rehospitalizations, left ventricular (LV) dysfunction, myocardial infarction, and all-cause mortality—were recorded. Elevated NT-proBNP levels were significantly associated with adverse events: patients with >500 pg/mL exhibited the highest incidence of LV dysfunction (72%), recurrent MI (60%), and mortality (28%), while no deaths occurred in those with levels <100 pg/mL. NT-proBNP levels above 100 pg/mL were strong predictors of recurrent ischemia and compromised cardiac function.
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