Project overview
This study introduces two novel stimuli-responsive hydrogels—HG1 (thermoresponsive) and HG2 (pH-responsive)—engineered to enhance modern wound care by adapting to local physiological changes. Developed through strategic polymerization and crosslinking, these hydrogels demonstrated desirable physicochemical properties validated by FTIR, SEM, and XRD analyses. HG1 exhibited superior swelling capacity (~1700%) and elasticity, making it ideal for wounds with high exudate and localized inflammation, while HG2 showed greater mechanical strength, moderate swelling (~1100%), and controlled drug release in response to pH changes—characteristic of infected or chronic wounds. Both hydrogels displayed significant antimicrobial efficacy against key pathogens and maintained high cytocompatibility, with cell viability exceeding 89%, indicating their safety for prolonged clinical use. Their drug release profiles differed appropriately: HG1 favored rapid release under elevated temperatures, whereas HG2 allowed for sustained.
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